Human resources, especially nurses, are the most dominant workforce in carrying out tasks in the management of hospital organizations, therefore, as the driving force for organizing hospital activities, nurse job satisfaction is very important to get attention from hospital leaders and management. The purpose of this study is to determine the effect of intrinsic motivation on nurse job satisfaction. This type of research is non-experimental quantitative research with a descriptive approach (cross-sectional survey) and associative analysis. The study was conducted at Royal Prima Marelan Hospital in March 2022. The population in this study was all nurses who worked at Royal Prima Marelan Hospital with a total of 151 nurses. The sampling technique used in this study was the Slovin Technique with a confidence level of 95%, and an error rate of 5%, obtained 139 samples. Chi-Square's analysis found that the variables of responsibility (p-value=0.023), award (p-value=0.002), achievement (p-value=0.006) had a value of < 0.05, thus Ho was rejected Ha accepted. Likewise, with multiple regression analysis, the intrinsic factor variable has a p-value of <0.05, and the most influential variable is the reward variable with an OR of 5,105. Conclusion partially and simultaneously the variable intrinsic factor of nurses affects job satisfaction The OR value obtained is 5,105 meaning that with the appreciation of employees, it has a 5.1.05 times chance of affecting the level of job satisfaction of nurses at Royal Prima Marelan Hospital.