| Pages : 63-68
DOI : 10.36346/sarjet.2023.v05i05.002
The world of science and engineering of sustainability and nanotechnology are in today’s scientific fabric are in the aisles of newer scientific divination. Environmental, energy and socio-economic sustainability are the utmost needs of the hour. In the similar vision, nanotechnology needs to be aligned with diverse areas of natural sciences, applied sciences and engineering sciences. The definition of “sustainability” as described by Dr Gro Harlem Brundtland, former Prime Minister of Norway needs to be re-envisioned, rethought and rejuvenated with the passage of scientific history and time. Human struggles, human scientific and engineering challenges and human impact needs to be rethought as environmental protection and environmental disasters are in the path of immense scientific contemplation. In this paper, the author deeply discusses with verve and validation the integration of nanotechnology and sustainability. Human race today stands in the middle of deep scientific disaster and also scientific contemplation. Loss of ecological biodiversity and frequent environmental disasters are urging the scientific and engineering community to move towards newer scientific innovations and newer environmental engineering tools. Thus the need of a comprehensive treatise in the field of nanotechnology and sustainable development. Nanotechnology has vast and varied applications in the field of environmental pollution control. The author deeply targets these areas of scientific and engineering research endeavor. A newer era in the field of nanotechnology, nano-engineering and sustainability will surely usher in if a concerted effort is taken in the proper implementation of United Nations Sustainable Development Goals and the vision of Brundtland Commission Report. A new generation of scientists and engineers will move towards positive research directions if man and mankind innovates and envisions the basics and fundamentals of environmental engineering science, chemical process engineering, sustainable engineering and nanotechnology.
Almohktar A. Adwas, Imran M. S. Almgatif, Azab Elsayed Azab
| Pages : 33-48
DOI : 10.36346/sarjap.2023.v04i03.002
Background: Doxorubicin (DOX) is an effective antineoplastic agent of the anthracycline group. However, as with most anticancer drugs, they cause some toxic effects, including major cardiotoxicity. Oxidative stress, inflammation and apoptosis contribute to the pathological basis of doxorubicin (DOX)-induced cardiotoxicity. Indole-3-carbinol is a cruciferous-derived phytochemical, with potential anti-inflammatory and antioxidant effects. Purpose: Our present study aimed to investigate the protective effects of I3C against DOX- induced cardiotoxicity in mice by Targeting Inflammation, Oxidative Stress, and Apoptosis. Methods: BALB/c mice were subjected to DOX (4 mg/kg/day, i.p.) once weekly on days 0, 7, 14, 21 (for 21 days) to generate DOX- induced cardiotoxicity. Indole-3-carbinol was administered daily orally in the diet at two dose levels; 1000 ppm and 2000 ppm for 7 days before and 42 days after first injection of DOX. Serum creatine kinase (CK-MB), lactate dehydrogenase (LDH) and troponin I (cTn-I) levels activities, which are cardiac function markers were determined. Also, the levels of malondialdehyde (MDA) was assessed and enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPx) were assessed in the heart tissues to determine the protective effect of Indole-3-carbinol against oxidative stress. To determine the anti-inflammatory effect, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) were assessed in the heart tissues. Parts of the heart were subjected to histopathological and immunohistochemical examinations. Results: Indole-3-carbinol in a dose‐dependent manner was found to have the ability to mitigate the harmful effects of DOX on myocardial muscles with significant decrease in serum levels of CK-MB, LDH and cTn-I. In addition, Indole-3-carbinol significantly inhibited DOX-induced cardiac oxidative stress as seen in the reduced level of MDA and increased SOD, CAT, GR and GPx cardiac tissue levels; Indole-3-carbinol significantly reduced inflammatory mediators TNF-α and IL-6 levels and inhibited cardiac apoptosis by modulating Caspase 3 cardiac tissue levels. Moreover, Indole-3-carbinol, in a dose‐dependent manner, had the ability to combat the histopathological and immunohistochemical changes induced by doxorubicin in cardiomyocytes. Conclusion: These results demonstrate that administration of I3C in a dose dependent manner prevents heart injury induced by DOX via its antioxidant, anti-inflammatory, and antiapoptotic activities.
| Pages : 105-118
DOI : 10.36346/sarjbab.2023.v05i05.001
This work was aimed at determining the antioxidant activity of an ethanol extract of Tetrapleura tetraptera fruits in rats administered DMH. Group 1 (positive control) contains rats without the administration of DMH, extract, or CMC. Group 2 (negative control) received DMH, 1 ml of 1% CMC, and no extract. Group 3 received a low dose of the ethanol extract of Tetrapleura tetraptera fruits (100mg/kg) and DMH. Group 4 received a high dose of the ethanol extract of Tetrapleura tetraptera (200mg/kg) and DMH. The DMH was administered once a week for four consecutive weeks, while the ethanol extract of Tetrapleura tetraptera was administered daily for four consecutive weeks. The result showed that there was a significant increase in the activities of SOD, CAT, and GST in rats administered an extract of Tetrapleura tetraptera fruits compared to the negative control group. In general, the introduction of Tetrapleura tetraptera to the rats caused an increase in the activity of the antioxidants compared to the negative control. The histopathological profile, however, showed that the DMH did not affect the liver, colon, and small intestine morphology. It could thus be concluded that the ethanol extract of Tetrapleura tetraptera fruit has potent antioxidant activity.
| Pages : 60-62
DOI : 10.36346/sarjet.2023.v05i05.001
Are investigated a trajectory of new type in distant, space flights unlike usual trajectories of direct flight to heavenly object (Moon) it is supposed to use asymmetry of a gravitational field and to carry out flight bypassing the most power gravitational impact on the spacecraft. It leads to economy of power for 20-30 %.
| Pages : 45-54
DOI : 10.36346/sarjaf.2023.v05i05.001
Malting barley is barley that will produce high quality malt. It is a specialty crop for which a premium price is paid by domestic maltters and exporters. Quality requirements for malting barley are reasonably strict and are directly related to processing efficiency and product quality in the malting and brewing industries. Many of the characteristics required are under the control of the producer. Others are determined by weather conditions during the growing and harvesting season. So this trial was conducted on eleven improved malt barley varieties at Fitche Agricultural Research Center for two consecutive years with the objective to identify adaptable, stable, high yielding and its malting potential. The experiment was layout in Randomized Complete Block Design with three replications. Nine agronomic traits data and four major malt quality parameters were evaluated. Analysis of variance detected significant difference among varieties for most observed traits both separated and combined analysis. Observation attained significant differences over years and locations for most traits. The combine ANOVA and the AMMI analysis for grain yield across environments revealed significantly affected by environments that hold 40.42% of the total variation. Genotype and genotype by environmental interaction were significant and accounted 38.11 % and 19.10 % respectively. Principal component 1 and 2 accounted 10. 9 % and 4.19 % of the GEI respectively with a total of 15.09 % variation, the interaction effect of variety by year and variety by location imposed significant effect on most traits. Among evaluated varieties; Singiten and EH1847 had significantly higher mean value of grain yield. Malt quality parameters were conducted in the laboratory of Food Technology and Process Engineering at Holleta Agricultural research center. The mean values of malt quality parameter had malt hot water extract, malt Friability, malt protein content and malt beta-glucan, 78.32%, 58.42%, 10.27% and 492.13mg/L respectively. The results obtained showed that most malt quality had differences among the varieties and some of the results found were within the acceptable limit of EBC (European Brewery Convention) standard even if a single variety may not fulfill all the quality requirements. Based on these findings, the Traveler and the HB1963 varieties fulfill some of the quality parameters that are specified in the EBC range.
Professor Aamir Abdullahi Hamza
Editor-in-Chief "South Asian Research Journal of Medical sciences"
Dr. Mohamad Fazli Sabri
Editor-in-Chief "South Asian Research Journal of Business and Management"
Dr. Fatmir Shehu
Editor-in-Chief "South Asian Research Journal of Humanities and Social Sciences"
Dr. Sunil Kumar
Editor-in-Chief "South Asian Research Journal of Agriculture and Fisheries"
Prof. Helme Ahmed Altaee
Editor-in-Chief "South Asian Research Journal of Oral and Dental Sciences"
Dr. Md. Habibur Rahman
Editor-in-Chief "South Asian Research Journal of Pharmaceutical Sciences"
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