The study was carried out to detection of H.pylori in (218) patients who attended two teaching hospitals in Baghdad. The diagnosis is done by Immunochromatography methods. Stools and blood samples were taken from each patient as well as other (30) healthy control matching in age. The study included measurement the Levels of Interleukin-17, Interleukin-23, and Alkaline phosphatase in sera of patients and control .The result indicated presence of H pylori antigen in 115 cases 59 cases of males and 51 of females , Also, the result indicated increasing levels of IL-17 and IL-23 and Alkaline phosphatase in patients sera in comparison with healthy control.