Background: Ischemic stroke is the foremost common cause of stroke around the world, bookkeeping for 10 times more strokes than hemorrhagic strokes in higher pay nations. There are proof accessible for each antiplatelet sedate utilized in the treatment of ischemic stroke. The advertised recommendations for elective restorative choices when confronted with repetitive stroke. Aim: To know the use of antiplatelet in ischemic stroke patients. Method: This study used a systematic review that searched using the keyword Antiplatelet and Ischemic Stroke in Google Scholar, Crossref, and PubMed. Recent studies in English published in 2012-2022. Result: After the final screening, the author analyzed 4 articles that were published after the year 2012. Conclusion: In spite of the fact that great proof exists for the utilization of certain antiplatelet operators for postischemic stroke, there are significant openings for future investigation to examine personalized treatments. These incorporate screening patients for platelet polymorphisms that bestow antiplatelet resistance and for randomized trials counting more racially different populations.