Ginger (Zingiber officinale) is one of the spice plants found in Indonesia that is useful as a drug, containing secondary metabolite compounds flavonoids, alkaloids, terpenoids, and essential oils that are antibacterial. The purpose of this study was to find out the comparison of the effectiveness of red ginger extract and ginger emprit against the growth of Staphylococcus aureus bacteria. This study is an Experimental Laboratories study using true experimental design with the design of Post Test Only Control Group Design. Where extracts of red ginger and ginger emprit are obtained by the maceration method which is then varied into several concentration treatments namely 20%, 40%, 60%, 80%, and 100% as well as positive control of ciprofloxacin and dmso negative control, followed by disc diffusion methods to test antibacterial activity, analyzed statistically using the One Way Anova test. The results showed that red ginger extract and ginger emprit were able to inhibit the growth of Staphylococcus aureus bacteria with weak to moderate activity. The final results showed a value of p<001 so that at least there was a meaningful average between the data groups of red ginger extract and ginger emprit. The conclusion of this study was that at a concentration of 100% red ginger extract was more effective in inhibiting the growth of Staphylococcus aureus bacteria with a bland zone of 17.83 mm compared to emprit ginger extract with a bland zone large of 17.16 mm. The advice we give that red ginger more quickly inhibits bacteria so it is very well consumed and becomes an alternative non-pharmacological treatment.