The Isoxazole ring system belongs to a much studied class of compound. In the last few decades, the chemistry of Isoxazoles and their fused heterocyclic derivatives have received considerable attention owing to their significant and effective biological activity. The present study aimed to design and synthesize novel derivatives of Isoxazole from 4-methoxy aniline gives N-(4-methoxyphenyl) acetamide which was hydrolysis with sodium hydroxide and treated aromatic aldehydes yields resultant compound N-(4-methoxyphenyl) 3-phenyl propanamide (BSM-IIIA-IIIJ). Title compound were synthesized and the structures of newly synthesized compounds were confirmed by IR, Mass and 1H-NMR spectroscopy. All the compounds synthesized were evaluated for their analgesic activity by using Eddy’s hot plate method. The compounds 5- (4-bromophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIID) and 5- (4-chloro-3-nitrophenyl)-N-(4- methoxyphenyl) 4,5- dihydroisoxazole-3-amine (BSM-IIIF) were shown good analgesic activity and remaining compounds were shown poor analgesic activity.