Pseudomonas aeruginosa is an opportunistic pathogen, gram-negative bacteria, able to colonize such injuries, gammaproteobacterium, found in different environmental such as soil and water. The sepsis of burn wounds causing a morbidity and mortality are complex microenvironments where infections by bacterial pathogens such as P. aeruginosa. The P. aeruginosa pathogenicity is intercede by its capacity to produce a big range of virulence factors which include biofilm formation and it is have resistance to antibiotics, environmental stresses and disinfectants, and heavy metals. The losses of the skin barrier and tissue destruction are part of the most devastating form of trauma and require medical care to maintain homeostasis.