In humans, the spleen is a highly compartmentalized organ. The structure, cell population, and functions are unique for each compartment. The red pulp comprises non-filtering lymphoid areas, the perifollicular zone that separates the red and white pulps, the red pulp cord tissue and sinuses, and the perivascular rim. B-follicles and T-cell areas can be found in the white pulp. The obtained specimens were divided into three groups: Group 1 (0 to 14 years), Group 2 (14 to 50 years), and Group 3. (Over 50 years). The results show diminish diameter of white pulp in spleen with aging in G1, G2, and G3 (279.39±50.61, 354.51±39.44, and 222.48± 46.24) respectively. Conclusion, the white splenic pulp's diameter decreases with advancing years.