The study reveals the effectiveness of games in learing English vocabulary of non English major students at the University of Transport and Communications out. In this study, the majority of the students supported the use of games as the best way of learning English vocabulary as well as showed their positive attitude after the treatment, as detected by the tests, questionnaire and interview. From the research findings, several further studies as well as suggestions for teachers were made in the hope of improving the teaching and learning English vocabulary in Vietnam University.