M. abscessus var. abscessus and M. abscessus var. massiliense are fast growing non-tuberculous mycobacteria that cause skin and soft tissue infections. We present a 32-year-old female that initiated her current condition two years ago prior her medical assessment due to an event of cellulitis in the front part of her legs and later on being in contact with contaminated water. Two weeks later after the exposure she developed a dermatosis in the same region characterized by disabling pain, intermittent fever and edema without achieving improvement after being treated with multiple topic treatments. For these reasons, extension studies were carried out to get to the diagnosis of infection related to Mycobacterium abscessus var. massiliense, this gave the opportunity to give a successful therapeutic approach. Finally, after being treated for a month, an adequate evolution was obtained.