The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an extraordinary setback in the global economy and public health. Vaccination is one of the most effective measures to significantly reduce severe illness and death from COVID-19. In recent years, there have been an increasing number of reports of new acute kidney injury (AKI) following COVID-19 vaccination. Podocyte injury, IgA nephropathy, vasculitis, tubulointerstitial injury, and thrombotic microangiopathy are considered to be the major pathological phenotypes. Nevertheless, whether the association between COVID-19 vaccination and acute kidney disease (AKD) is causal or chance remains to be tested. Indeed, it is undeniable that mass vaccination against COVID-19 will bring significant benefits in preventing morbidity and mortality from COVID-19. The study included the effect of the Corona vaccine on kidney functions and blood variables MCV, HGB, among vaccinated adults aged (18-32) years in Anbar province, auditors Ramadi Teaching Hospital and Anah General Hospital.40 blood samples were collected and a test was conducted for blood variables and kidney functions (creatinine and urea), and it was found that the percentage of urea and creatinine has increased among the vaccinated compared to its percentage when the unvaccinated, and that the percentage of MCV, HGB decreased among the vaccinated compared to the unvaccinated, as the study showed that the percentage of urea was among the unvaccinated (21.7) while among the vaccinated (36.41). Creatinine was among the unvaccinated (0.695) while among the vaccinated (1.041). The MCV rate among the unvaccinated (85.86) while among the vaccinated (82.74) and the percentage of HGB among the unvaccinated (13.58) while it was among the vaccinated (12.37).