The orthopoxvirus, which also includes the smallpox virus, is what causes monkeypox. Several endemics have been found in Africa, mostly in the western and central parts of the continent. But since May 13, 2022, several cases have been reported from different member states. The number of proven cases in one month was higher than the total number of cases recorded outside of Africa since the first case in 1970. The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) think that monkeypox is a very important disease for the health of people around the world. Patients with monkeypox still don't know what symptoms they will have or what lab tests will show. We talk about a young man with HIV and Type C hepatitis who got a serious monkeypox virus that caused major skin problems.