The purpose of this study was to analyze and prove the relationship of Job Characteristics and Transformational Leadership on Organizational Commitment and Altruism and Its Effect on Nurses’ Satisfaction and Performance in Private Hospitals in Samarinda City. The design of this study was explanatory research. The type of this research was observational study using a cross-sectional research design. The method used to collect the data in this study was survey method. The population of this study was nurses at Private Hospitals in Samarinda City. In this study, Slovin formula was used as the sampling method obtaining total of 225 respondents, while the data collection process used simple random sampling. This study used Structural Equation Modeling Partial Least Square (SEM-PLS) approach to analyze the data. The results of this study can be summarized as follows: Job characteristics provide a positive and significant effect on nurses’ organizational commitment. Job characteristics provide a positive but not significant effect on nurses’ satisfaction. Job characteristics have a positive but not significant effect on nurses’ performance. Job characteristics have a positive and significant effect on nurses’ altruism. Transformational leadership has a positive and significant effect on nurses’ organizational commitment. Transformational leadership has a negative but not significant effect on nurses’ satisfaction. Transformational leadership has a positive and significant effect on nurses’ performance. Transformational leadership has a positive but not significant effect on nurses’ altruism. Organizational commitment has a positive and significant effect on nurses’ satisfaction. Organizational commitment has a positive and significant effect on nurses’ performance. Altruism has a negative and insignificant effect on nurses’ satisfaction. Altruism has a positive and significant effect on nurses’ performance. Nurses’ satisfaction provides a positive and significant effect on the performance of executive nurses at Private Hospitals in the City Samarinda.