Background: The period of transition from High School to University presents a significant challenge for students, requiring them to adapt to a new learning environment and take on increased responsibilities. Objectives: This study aimed to assess the adaptation of freshmen to College life, associate the adaptation of freshmen to college life with their demographic variables and correlate the Academic/ Personal/Social and Institutional Adaptation of Freshmen to College life. Methods: A quantitative approach using a descriptive cross-sectional design was employed. A total of 201 freshmen were selected from a private University in Ajman, UAE. Data were collected through the Student Adjustment to College Questionnaire (SACQ). Results: The findings indicated that 86% of freshmen exhibited moderate levels of adaptation, while 10% demonstrated higher levels. Additionally, a significant difference was observed between male and female freshmen, with females showing higher levels of adaptation. Furthermore, the findings revealed a significant association between freshmen's gender and demographic factors at a 0.05 level of significance. There was a significant positive correlation between all four components namely Academic Adaptation, Personal Adaptation, Social Adaptation and Institutional Adaptation. These findings shed light on the challenges faced by freshmen during the transition to University life and highlight the influence of demographic variables on their adaptation process.