Pulmonary tuberculosis is increasing at alarming rate with high level of resistance to chemotherapy. The study was done to determine the changes in haematological parameters in relation to ranges of CD4 of patients with pulmonary tuberculosis before treatment in Southeast, Nigeria. A total of one hundred subjects were recruited for the study comprising 50 subjects each for Patients with pulmonary tuberculosis before treatment with CD4 count of 100-200 cell/L and 201-300 cells/L drawn from the Health institution. The study was done in a tertiary health institution in Southeast, Nigeria. Three milliliters (3ml) of venous blood was collected from each subject and was dispensed into bottles containing di-potassium salt of ethylenediamine tetra-acetic acid (K2-EDTA) at a concentration of 1.5mg/ml of blood and was used for full blood count and CD4 count. Haematological parameters were analysed using Mindray BC-5300. The results were expressed as mean± standard deviation. The data were analysed with the statistical package for social science (SPSS) version 21 using t-test, ANOVA and the level of significance was set at P<0.05. The results showed decrease in neutrophil (61.85±1.94%, 63.94±2.99%, P= 0.046) and MCV (78.09±1.64fl, 79.50±1.02fl, P=0.015) and no significant difference in WBC (5.53±0.36 X109/L, 5.32±0.58 X109/L, P=0.285), lymphocytes (23.08±2.21%,21.16±3.16%, P=0.087), monocytes (11.37±0.81%,11.49±1.06, P=0.766), eosinophils (2.28±0.61%, 2.16±0.33, P=0.574), basophils (1.42±0.26%, 1.23±0.24%, P=0.126), RBC(3.64±0.20 X1012/L, 3.63±0.18 X1012/L, P=0.839), haemoglobin (10.93±0.60g/dl, 10.89±0.55g/dl), PCV (32.80±1.80%,32.66±1.64%, P=0.840), MCH (27.47±0.49pg, 27.55±0.32pg, P=0.646), MCHC (35.14±0.45g/dl, 35.31±0.36, P=0.306), Platelet (140.81±3.28 X109/L, 141.12±4.05 X109/L, P=0.833) and ESR (47.66±2.36mm/hr, 47.46±2.98mm/hr) of the of TB patients based on ranges of CD4 counts. The study shows that the range of CD4 count has no much changes in haematological parameters except decrease in neutrophil and MCV.