Malaria is an endemic disease in Sudan as well as in many developing countries. The emergence of antimalarial drugs resistance represents a serious problem disturbing the health community throughout the world. Acidity reduces absorption of antimalarial drugs and allows for malaria parasites to survive and multiply. Gastrointestinal pathogens such as Entamoeba histolytica, candida and Helicobacter pylori may support the growth of Plasmodium falciparum, through inhibition of the absorption of Artemether/lumefantrine and offer resistance of interest to malaria parasites. Antimicrobial agents such as tinidazole in case of acidity of microbial origin and antiacids in case of anxiety the resulting acidity may support the action of Artemether/lumefantrine in addition to other antimalarial agent to overcome their absorption defect.