Radiotherapy is a cornerstone in the treatment of Hodgkin's disease but can have long-term consequences, notably the development of secondary malignant tumors. This case study and literature review highlight the imaging characteristics, diagnostic challenges, and clinical outcomes of this late complication. The aim of this article is to underscore the role of imaging modalities in the diagnosis, characterization, and management of this rare and complex condition. We discuss the radiological findings, clinical diagnosis, and therapeutic considerations, thereby providing valuable insights into radio-induced breast cancer in Hodgkin's disease and emphasizing the importance of personalized surveillance in these high-risk patients.