The study investigated the anti-ulcerogenic and hepatoprotective potential of the methanolic extract of Andrographis paniculata in Wistar albino rats with aspirin-induced ulcer and liver damage. The study measured the following parameters: AST, ALT, ALP, and MDA. A total of 50 rats (weighing about 150-300g) were divided into 5 groups of 10 rats each. Group 1 (Normal control), group 2 (Positive control) were given normal saline(10ml/kg), Group 3(Test 1) and Group 4(Test 2) received 200 mg/kg and 400 mg/kg of the extract, respectively, and group 5 (standard), received 30mg/kg of Omeprazole for 7days. On day 7, rats in groups 2, 3, 4, 5 were fasted for 24hrs and, on the 8th day, were induced with 10mg/kg of Aspirin orally. The animals were sacrificed on day 9 under chloroform anaesthesia, and blood was collected via cardiac puncture for liver function assay. Parts of the liver and the GIT of the rats was harvested and fixed in 10% chlorororm for histological studies while the liver and GIT were homogenized for lipid peroxidation assay. The study discovered that Serum AST, ALT and ALP. levels were significantly increased (p <0.05) in positive control compared to the normal control. However, pretreatments with Andrographis paniculata (200mg/kg and 400 mg/kg) in test1 and 2 significantly decreased the activities of serum AST, ALT, and ALP, compared to those in group 2 (positive control). In addition, treatment with. The activity of the GIT SOD was decreased in positive compared to normal control. Test 1 and 2 pretreated with Andrographis paniculata (200mg and 400 mg/kg) respectively demonstrated significant increase in the activities of MDA compared to positive control. From the Histology of the GIT Positive control shows Sections areas of ulcerated epithelium with atrophic gastric glands compared to Test 1 and 2 which shows gastric mucosa with the disappearance of the original gastric glands and other epithelium replacements and healing by fibrous respectively. In conclusion, the methanolic extract of Andrographis paniculata demonstrated antioxidant properties that conferred hepatoprotective and anti-ulcerogenic effects in the aspirin-induced ulcer and liver damage model in Wistar albino rats. The higher dose of the extract (400 mg/kg) exhibited more pronounced protective effects compared to the lower dose (200 mg/kg).