This study aimed to assess the preventive properties of the methanol extract of Andrographis paniculata on the development of ulcers and liver damage in Wistar albino rats. The rats were divided into five groups, each consisting of 10 rats. The groups were given different dosages of Andrographis paniculata extract, omeprazole, orally, orally, and ethanol orally. The liver tissues were then examined for lipid peroxidation. The results showed that the extract of Andrographis paniculata showed substantial efficacy in preventing liver damage caused by ethanol. The levels of malondialdehyde (MDA) in the positive control group were significantly higher (p < 0.05), than those in the normal control group. The administration of Andrographis paniculata at doses of 200 mg/kg and 400 mg/kg in groups 3 and 4, respectively, resulted in a statistically significant decrease (p < 0.05), in MDA levels. The administration of omeprazole at a dosage of 30 mg/kg also resulted in a notable reduction (p < 0.05), in MDA levels. The positive control group exhibited a significant increase (p < 0.05), in serum AST, ALT, and ALP levels, while a decrease (p < 0.05), in total protein and albumin levels. The administration of Andrographis paniculata at doses of 200 and 400 mg/kg, as well as omeprazole at a dose of 30 mg/kg, led to a significant reduction (p < 0.05), in AST, ALT, and ALP levels, and a significant increase (p < 0.05), in total protein and albumin levels compared to the positive control group. The findings suggest that the methanol extract of Andrographis paniculata may contain antioxidant compounds that exhibit hepatoprotective properties.