Background: Diabetic ketoacidosis represents a life-threatening complication of diabetes, standing as the foremost cause of mortality associated with the condition. The proficient management of patients suffering from diabetic ketoacidosis hinges upon the expertise and proficiency of nurses, who play a pivotal role in the comprehensive care and treatment of these individuals. Aim: The objective of this study was to assess the knowledge of nurses in the Department of Medicine and Intensive Care Unit at Moulay El Hassan Ben El Mehdi Hospital concerning the biological and clinical parameters, as well as the management protocols, for patients diagnosed with DKA. Methods: A self-administered questionnaire was distributed to nurses working in both the Department of Medicine (n=8) and the Intensive Care Unit (n=10) at Moulay El Hassan Ben El Mehdi Hospital in Laâyoune. The questionnaire included variables covering demographic characteristics, clinical information, and biological parameters. Results: The majority of nurses (88.8%) demonstrated adequate knowledge regarding the definition of DKA, with most nurses in both departments displaying familiarity with the biological and clinical manifestations of the condition. In terms of management practices, all nurses reported utilizing saline solution or glucose serum based on the patient's blood glucose levels. Conclusion: The study suggests the implementation of standardized educational programs within intensive care units to enhance nurse staffing, improve the level of patient care, and elevate the quality of care delivered to this patient demographic.