Rift Valley fever (RVF) is an acute arthropod-borne viral disease that can cause severe disease in domestic animals, such as buffalo, camels, cattle, goats, and sheep. Rift Valley fever is also an important zoonosis that can cause severe disease in humans. This article will provide complete information regarding the historical background, mode of transmission, clinical signs and symptoms, clinical complications and new insights including pathogenesis, differential diagnosis, treatment & prevention.