Community pharmacists, like other health care providers, have a crucial role in controlling and preventing the spread of the COVID-19 virus. They should possess adequate knowledge to help in the response against this infection. This study assessed the knowledge and preparedness of community pharmacists working in community pharmacies within a component city in northern Philippines. A descriptive quantitative design was used. Sixty community pharmacists responded to the online survey of a structured questionnaire. Data were analyzed using frequency and percentage and mean while tests to determine significant difference were done using Independent Samples T-test and One-way ANOVA. Results showed that the community pharmacists are fully knowledgeable about the signs and symptoms, screening guidelines, and transmission prevention for COVID-19. Furthermore, the community pharmacists were fully prepared to manage or control COVID-19 transmission and implement preventive measures to address the pandemic. There is no significant difference in the knowledge and preparedness of the community pharmacist when grouped according to demographic profile. Moreover, there is no significant relationship between the knowledge and preparedness of the community pharmacists toward COVID-19. The researchers conclude that community pharmacists possess the knowledge and preparedness needed to help in the effective response against COVID-19.