Taxanes are a diverse class of chemotherapeutic agents. Cutaneous toxicity has been reported with taxanes and includes erythema and desquamation, involving primarily the hands. Nail changes are described in different series and case reports, but the real incidence of this side-effect is probably underestimated, literature reports that adverse events occur in up to 89% of patients. The nail changes caused by chemotherapy in cancer patients are difficult to assess and often overlooked by clinicians.