A rise in the number of women suffering from SLE has been noted by researchers. The research comprised 70 patients and thirty healthy normals. They were between the ages of fifteen and fifty-three; the sample was gathered from different clinics in Iraq. The Blood samples were taken for serum isolation. The serumis used for evaluation of serum glucose level, triglyceride level, cholesterol level, alanine transaminase (ALT), aspartate transaminase (AST), urea nitrogen level, uric acid. The results showed that AST and ALT were increased significantly in SLE patients. cholesterol and triglycerides have increased significantly, according to biochemical tests. Serum glucose, urea nitrogen, and uric acid levels changed by a negligible amount. In conclusion, SLE has an effect on liver functions and lipid profile while it doesn’t affect Kidney functions and fasting glucose levels.