Calciphylaxis is a progressive, inflammatory disease characterized by the calcification of small and medium-sized arteries, leading to thrombotic ischemia. It is commonly associated with patients with chronic kidney disease; however, it can also manifest in patients without uremia. The incidence in patients undergoing dialysis can vary from 0.04% to 4%; it can affect multiple organs including the skin, brain, lungs, and muscle. Hyperphosphatemia, hypercalcemia, and hyperglycemia are common biochemical conditions in patients with this disease that induce the transformation of vascular smooth muscle cells into osteoblast-like cells, thus establishing the mechanism for vascular calcification through the formation of ectopic bone within the vessel wall. Additionally, there is a deficiency of calcification inhibitors in patients with chronic kidney disease. These factors promote the hardening and narrowing of affected arterioles, compromising their structural integrity and fostering an environment conducive to thrombosis. Cutaneous calciphylaxis can present as non-healing nodules, plaques, and ulcers. Currently, biopsy and histological analysis are the methods of choice for diagnosis. Treatment is multidisciplinary and includes early surgical debridement, symptom management, and modification of risk factors. We present the case of a female in her fifth decade of life with a history of chronic kidney disease who developed calciphylaxis with cutaneous manifestations requiring surgical treatment.