Introduction: Chronic diabetes leads to dyslipidaemia. Patients with dyslipidaemia, the most common risk factor for cardiovascular disease, also have a higher risk of severe evolution of COVID-19. Objective: To study the characteristics of lipid profile disorders in COVID-19 positive type 2 diabetic patients in Pointe-Noire. Methods: We recruited a total of 206 participants for this study. Detailed information on age, gender, and health status of participants was collected from medical records. Biomarkers were quantified from blood samples and the sars cov-2 virus was identified using the PCR technique on nasopharyngeal swabs. Results: The majority of patients were male (70.39%), COVID-19 severe symptoms (67%) and comorbidities (57.77%) were more common. CT↑39%, LDL↑36%, HDL↓77% and TG↑68% in non-survivors were found in patients with severe disease severity. A positive correlation between atherogenic indices (AIP, CRR and AC) with TC, LDL and TG then, an inverse linear relationship with HDL. There was also a negative correlation between CPI and HbA1c. Conclusion: The results of our study show that T2DM with severe signs of COVID-19 have high levels of harmful lipids (TG, CT and LDL) and high atherogenic indices (AIP, CRR and AC), while low levels of HDL, a cholesterol-trapping lipoprotein, and low CPI correlate negatively with HbA1c.