Background: Cancer patients increasingly seek complementary and alternative therapies (CAM) alongside conventional treatments. Herbals represent a significant component of CAM, with growing interest in their potential anticancer properties. Objective: This review critically examines the role of herbals in cancer management, exploring their mechanisms of action, clinical evidence, potential for synergy with conventional therapies, challenges and perspectives, and patient perspectives. Methods: A comprehensive literature search was conducted using PubMed, Google Scholar, and other relevant databases. Studies investigating the mechanisms, efficacy, safety, and patient experiences with herbals in cancer management were reviewed. Results: Herbals exhibit diverse mechanisms of action, including anti-proliferative, anti-angiogenic, and immune-modulatory effects. Clinical evidence suggests promising results for certain herbals, such as curcumin and ginseng, in improving treatment outcomes and reducing side effects. However, safety concerns and the need for standardization and quality control remain challenges. Conclusion: Herbals hold potential as complementary therapies for cancer management, offering a holistic approach that empowers patients and improves their quality of life. Further research is crucial to optimize their integration with conventional therapies, ensure safety, and establish evidence-based guidelines for their clinical use.