The current study aimed to know the negative effect of children with acute tonsillitis on CBC values and inflammatory indicators. ESR where the study included 50 children whose ages ranged from 5-10 years. Examples of experiment were divided into two groups 25 children for the first group, who were healthy from the injury. As for the second group, they are 25 children with acute tonsillitis. Al -Razi Laboratory, Al -Rafah and Al -Ahly Hospital Laboratory in Al -Hawija district. The current study's findings demonstrated a noteworthy rise in White Blood Cell (WBC) in children with acute tonsillitis compared to healthy children, while the results of the study in Red Blood Cell (RBC) showed a significant increase in healthy people compared to the affected children, while platelet values and values showed PCV is that there are no moral differences between the injured and the healthy, as the results showed that there is a moral rise in random sugar values and ESR values.