Dermatophytes infection is a common problem worldwide and frequent in Iraq. Several reports and articles were published on prevalence, distribution, causes and treatment of dermatophytosis. The current study included the collection of 100 clinical samples (70 skin peels, 20 hair samples and 10 nail samples), as well as 50 blood samples from patients with dermatophytes and skin consultants in Tikrit City and 20 healthy blood samples for the period from November 2023 to March 2024. The results showed that the most common dermatophytes isolated was Microsporum canis and T.rubrum 10 (20 %) isolates from 50 total , followed by M.gypseum, 6(12%) and 5(10%) T.mentagrophytes and T.verrucosum and 4(8 %) isolates E. floccosum and T.erinacei and finally appeared 3(6 %) isolate T.schoenleinii and T.concentricum. The results of the statistical analysis showed non significant difference P <0.05 in the total number of white blood cells and monocyte (5.15 ± 2.636, 0.89±0.51) in patients with dermatophytes compared with the group Control mean± SD (5.73±1.821, ± 0.69 ± 1.591) respectively. Lymphocytes significant decreased (1.82 ± 1.301) in patients with dermatophytes compared to control group (4.60 ± 1.35) P≤0.01. Furthermore granlocytes increased (2.30±1.591) in patients with dermatophytes compared to control group (0.33± 0.403) P<0.01. The study concluded that perhaps the reduction of some of the body's WBCs parameters has an important role in the incidence of fungal infection in people infected with them when compared to healthy people.