Background: One important cytokine that modulates the immune response during infections is IL-6. Gaining knowledge about the correlation between IL-6 genetic variants and susceptibility to disease can be quite beneficial in understanding the pathophysiology of various illnesses. Objective: Present study aims to explore the relationship between the polymorphisms IL-6-174 G/C and IL-6-597 A/G and their potential role in disease susceptibility and progression. Methods: A 210 adenovirus respiratory patients at Baghdad Hospital. Patients with comorbidities or previous respiratory infections were excluded. Nasopharyngeal swabs were collected and tested for adenovirus using PCR. From the specimen, genomic DNA was isolated. Genotyping PCR-RFLP was used to genotype the Interleukin-6 (-597 A/G, rs 1800797) polymorphism. Results: Interlukin-6-174 G/C polymorphism and illness sensibility are strongly correlated, according to the study's findings. More precisely, it was found that both a worse development and a race probability of contracting a severe COVID-19 infection were analogous with the IL-6-174 G/C polymorphism. In addition, it was linked to the periodontitis probability. Discussion: Current studied results point to the potential importance of the IL-6-174 G/C polymorphism in disease vulnerability, especially in cases of acute COVID-19 infection and periodontitis. However, as there is no proof of a strong association between the IL-6-597 A/G polymorphism and type 2 diabetes or malignant tumors, its significance in detected disease susceptibility remains unclear. Conclusion: Our study highlights the potential role of IL-6 genetic variations, including IL-6-174 G/C, in the development and vulnerability of illness. To understand how these genetic polymorphisms affect the course of disease and their molecular relationship, more research is required.