Background of Study: Polycystic Ovarian Syndrome or disease (PCOS/PCOD), originally described in 1935 by Stein and Leventhal, is a complex, heterogeneous disorder of uncertain etiology, with a large degree can be classified as a genetic disease. It is thought to be the most frequent endocrine problem of women in reproductive age. In India nearly 40% of the women are affected by polycystic ovarian syndrome or disease (PCOD). But among then only 60% come to hospital for treatment, when they recognize that they have got infertility. Method: Evaluative approach is adopted to study as its aim is to test hypothesis that establishes relationship between polycystic ovarian syndrome (PCOS) and reduction in conditions. Pilot study was conducted with six samples in selected college to refine methodology and to find feasibility of study. Result: There was significant improvement in the knowledge of students following the administration of structured teaching program on Polycystic Ovarian Syndrome. Conclusion: The present study attempted to assess knowledge regarding polycystic ovarian syndrome. The study findings showed that the post test score was higher than the pre-test score and was concluded that structure teaching program on polycystic ovarian syndrome was effective.