This study aimed to detect K1, K2, and MagA genes in Kebsiella pneumonia patients and IL-10 levels. The study included 30 samples from variant patients' swabs (urine, wound). Then, cultured in McConkey media for 24 hours, purified the isolated samples and extracted bacteria DNA to work on conventional PCR. The study shows the advanced assay acceptably well-known ten isolates (33.3%) as K1 and 11 isolates (36.6%) as K2 serotypes, magA 14 isolates (46,6%) among 30 isolates of K. pneumonia serotypes. The immunological detection of IL-10 from 30 patients in the current study showed a high increase (83.3%) in K. pneumonia. There was high virulence from k1, k2 and magA in K. pneumonia patients, and the levels of interleukin-10 increased to inhibit the infection.