Examination using susceptibility tests of 112 urine sample revealed that the Escherichia coli is the mostly causative agent of women urinary tract infections in Kirkuk city. the high resistance rate %82.2 of E.coli was found to be against Clindamycin, where as other 32 bacterial isolation were exhibited multidrug resistant to 5 antibiotics used in this study . and lowest number of multidrug resistant isolates nine in total is resistance to six anti biotic .and all isolation were sensitive to Imipenem.