Previous studies have reported a positive influence of zirconium oxide nanoparticles on plants, the present effort was conducted to investigate the impact of two distinct concentrations of biosynthesized zirconium oxide nanoparticles (75 and 150 mg L-1) on the physiological and antioxidant responses of Vicia faba Plants. Zirconium oxide nanoparticles (ZrO2NPs) were synthesized using Matricaria chamomilla L. plant extracts. And their morphology and extent were determined Using X-Ray Diffraction and Transmission electron microscopy The diffuse reflectance spectra were measured using UV-Vis spectroscopy, the response of V. faba plants to foliar sprays regarding concentrations of (0, 75 and 150 Mg / l-1) M-ZrO2NPs was studied. The largest concentrations of chlorophyll a and b, carotenoids. Total pigments were documented in plants receiving 75mg / l-1 of M-ZrO2NPs associated to the control, secondary metabolite (Phenolics, Flavonoids, and Tannins) were gathered in response to M-ZrO2NPs treatment Glycosides, Terpenoid, Alkaloids (Mayer reagent) and Fuocoumarins. Moreover Tannins, Resins and Saponins, in addition to the levels of enzymatic and non-enzymatic antioxidants, rose by about two-fold in plant exposed to M-ZrO2NPs compared to control plants. The nitrogen, phosphorus, the contents of bean plants in terms also potassium, calcium, zinc, iron were noted in response to two applied quantities of M-ZrO2NPs. Spraying shrubberies by 75 Mg /l-1 of M-ZrO2NPs promoted plant development in addition to the buildup of antioxidants, osmolytes, and secondary metabolites that can help plants cope with the harmful consequences of environmental stress.