Email: submit@sarpublication.com (24x7 Online Support)
South Asian Research Journal of Medical Sciences (SARJMS)
Volume-2 | Issue-04
Case Report
Full Recovery from Symptomatic Lassa fever with Overt Bleeding without Ribavirin Therapy: A Case Report
Chukwu, Sunday Kyrian, Unigwe, Sonny Uche, Iroezindu, Michael Onyebuchi, Mmerem, Juliet Ijeoma, Umenzekwe, Chukwudi, Obeagu, Emmnuel Ifeanyi
Published : Aug. 13, 2020
DOI : 10.36346/sarjms.2020.v02i04.003
Abstract
Lassa fever (LF) is a viral haemorrhagic fever (VHF) endemic in West Africa including parts of Nigeria. Ribavirin has been shown to have therapeutic benefits especially if commenced within six days of the symptoms. After seven days, patient with LF tend to progress to clinical stage 3 characterized by multiple complications including bleeding with poor prognosis. We report a case of LF with clinical stage 3 symptoms, which made full recovery without ribavirin therapy. This is a case report of confirmed LF case managed at University of Nigeria Teaching Hospital Ituku/Ozalla. LF was confirmed using RT-PCR of venous blood sample. Other investigations performed include liver function test (LFT), serum electrolyte, urea and creatinine (SEUC), full blood count (FBC), urinalysis. A 24 year old male was referred from private hospital with two weeks history of fever associated with myalgia, anorexia and bleeding per rectum significant enough to require blood transfusion. A preliminary diagnosis of sepsis with bleeding diathesis was made. Although the FBC and SEUC findings were within normal limits, findings of elevated transaminases (AST > ALT), haematuria and proteinuria heightened the clinical suspicion of LF. He was managed conservatively with intravenous fluids, antipyretics, antibiotics, blood transfusion and nutritional support. Empirical ribavirin therapy was not possible due to unavailability of the drug. After eight days, his symptoms resolved and no new complications were observed. He was counseled and discharged home on request. Lassa virus RT-PCR result received after his discharged turned out positive. Contact tracing was carried out but none of his primary contacts developed symptoms of Lassa virus infection. He has remained stable. Individuals suffering from LF and its complications could potentially experience favourable prognosis following optimal conservative management if ribavirin is unavailable. This information is useful for management of LF in resource-limited settings.

About Us


South Asian Research Publication (SAR Publication) is a publisher for scientific online and print journals started with collaboration with other scientific organizations, institutions, academicians and researchers. SAR Publication is keen to make itself as a leading publisher for scientific and academic journals with quality peer review and rapid publication... Read More Here

Copyright © SAR Publication, All Rights Reserved

Developed by JM