The cross sectional study was determined the effective of dapagliflozin in lipid profile and cytokine in diabetic patients. The study was performed on 50 patients with diabetic mellitus in age between 40-65 years (22 males and 28 females) in Tikrit city from June 2023 until August 2024. The study was showed the significantly decreased the triglyceride level p < 0.01, cholesterol level p < 0.005, low density lipoprotein level (LDL) p < 0.005 and very low density lipoprotein level (VLDL) p < 0.005 and significantly increased high density lipoprotein level (HDL) p < 0.005. Potential side effects of the treatment include frequent urination, dizziness, or lightheadedness. When getting up from sitting or lying down, rise slowly to prevent dizziness and lightheadedness, although it could increase the chances of developing genital thrush and urinary tract infections. Also the study explained the significantly decreased the cytokine p< 0.005. The aim of the current study has study the effective of dapagliflozin on lipid profile and cytokine.