Background: Ichthammol, derived from shale oil, it is purported to have antimicrobial, anti inflammatory, antipruriginous, and analgesic properties. It is also believed to promote blood flow and act as a decongestant. It has been employed in the therapy of psoriasis, eczematous dermatitis, leg ulcers, seborrheic dermatitis, and furuncles. Objectives: To evaluate the efficacy and safety of topical Ichthammol for treatment of mild plaque psoriasis. Patients and methods: This therapeutic interventional study was conducted in Baghdad training center of Dermatology and Venereology for period from April 2018 to May 2019. A total of 34 patients with mild plaque-type psoriasis were evaluated. They were 19 (56%) males and 15(44%) females. Their ages ranged from 7-65 years with Mean± SD (32±17.2). Split test used for each patient, each patient divided into right and left side and some patient divided into anterior and posterior parts according to psoriasis location, Ichthammol used to the right and anterior side and Vaseline used for left and posterior side. both Ichthammol and Vaseline were used twice daily. Assessment of drug efficacy was based on the reduction of PASI score. Results: The degree of response to total course of treatment with Ichthammol in comparison with Vaseline showing that 27 patients on Ichthammol had less than 25% clearance rate while 21 patients had clearance rate <25% with Vaseline, while 5 patients on Ichthammol and 7 patients on Vaseline had showed clearance between 25-50%. Also 2 patients on Ichthammol in comparison with 7 pts on Vaseline had showed 90% clearance rate. According to side effect Vaseline showed no side effect but ichthammol had showed burning sensation and irritation in 7 patients. Conclusion: Ichthammol is not a cost-effective non significant drug for psoriasis while Vaseline was significantly better.