Rheumatoid arthritis (RA) is a chronic autoimmune disease with profound consequence tos for individuals and society. Characterized by persistent joint inflammation and progressive damage, RA leads to physical disabilities, psychological distress, and reduced quality of life. Beyond its impact on individuals, RA imposes a significant societal burden, including increased healthcare expenditures and loss of productivity, resulting in economic challenges. The disease is further complicated by comorbidities such as anemia, cardiovascular disorders, and infections, necessitating a multidisciplinary approach to care. Hematologists play a pivotal role in managing hematological complications and monitoring biomarkers for disease activity. Meanwhile, nursing managers contribute to patient education, adherence to treatment protocols, and coordination of multidisciplinary care. This article examines the wide-ranging impact of RA and explores the roles of hematologists and nursing managers in addressing its multifaceted challenges, offering insights into strategies for improved outcomes and reduced societal burden.