Background: Syringomyelia (Syr) is a rare, progressive neurological disorder characterized by the formation of a fluid-filled cavity (syrinx) within the spinal cord, leading to sensory and motor dysfunction. It is challenging to cure, and available treatments often have limited effectiveness. Recurrence is commonly observed after treatment. Objective: This study explores the role of Guan Yin Citta Dharma Door in managing Syr, presenting 2 cases in which Dharma practice led to significant symptom relief. Methods: This study examines two cases of patients diagnosed with Syr who adopted Buddhist practices based on the teachings of Dharma Master Jun Hong Lu. The first patient practiced making vows, reciting Buddhist scriptures, and liberating lives, with progress assessed through symptom relief and overall well-being. In the second case, the patient incorporated Dharma practices to aid recovery following surgery. Results: Through dedicated Dharma practice, the patient in Case 1 experienced significant symptom improvement, reduced pain, and survival beyond the medically expected prognosis. Similarly, in Case 2, Buddhist practices not only supported post-surgical recovery but also alleviated persistent pain and emotional suffering, leading to a profound transformation. These cases underscore the potential benefits of spiritual healing in managing Syr. Conclusion: This study suggests that Guan Yin Citta Dharma Door may provide an alternative approach to improving the quality of life in patients with Syr. While further research is needed, the integration of Dharma practices with conventional treatments may offer a more holistic strategy for managing neurological diseases.