Penile cancer is a rare disease, but its global incidence is on the rise. Human papillomavirus (HPV) is the primary risk factor, making HPV status assessment an essential part of pathological evaluation. The primary goal of treating the tumor is complete eradication while preserving as much of the organ as possible without compromising oncological outcomes. Early detection and treatment of lymph node (LN) metastasis are crucial for survival. In our case, the patient had a high-risk advanced penile cancer (PSCC) which had requirring a multimodal treatment approach, combining chemotherapy, radiotherapy with consolidation surgical treatment.