The current study aims to know the interactive role of the empowerment strategy at Wasit University and to know the importance of the relationship between organizational culture and proactive behavior through application in one of the Iraqi universities. Through this, (empowerment strategy) was adopted as an independent variable represented by (power, knowledge, information, rewards) and the interactive variable represented by (organizational culture) and its dimensions (organizational values, organizational beliefs, organizational trends, organizational expectations) was adopted. (Proactive behavior) was adopted as a dependent variable represented by the following dimensions (taking responsibility, worker voice, worker creativity, prevention of problems). The study problem was represented by the question that stated (Is there an interactive role for the empowerment strategy in the relationship between organizational culture and proactive behavior at Wasit University, College of Administration and Economics), while the study sample was represented by all employees in the College of Administration and Economics at Wasit University. In order to determine the relationship between the variables, a set of main and sub-hypotheses were developed. The questionnaire form was designed as a main tool for collecting data and information based on ready-made measures to discover the relationships of influence and correlation between the study variables. The researcher distributed (214) questionnaires, which were retrieved. (197) There were (17) non-returnable questionnaires and (20) questionnaires that were not valid for analysis. The final total became (177) valid for analysis.