The study's purpose was to examine the measures and mechanisms for the realisation of effective supervision of teaching and learning at Junior High Schools in Krachi Nchumuru. The qualitative research approach and the case study design were used. Headteachers and teachers of the junior high schools in Krachi Nchumuru constituted the population of the study. The convenience sampling method was used to select seven (7) head teachers and fourteen (14) teachers, making a sample size of twenty-one (21) participants. Face-to-face in-depth individual interviews were used to gather in-depth information from participants. Permission to conduct the study was sought from the education authorities. Data were collected using tape recording. Each interview lasted for 30 minutes. Collected data were transcribed and later analysed using the thematic analytical method. The findings regarding the measures and mechanisms for the realisation of effective supervision of teaching and learning include teachers exhibiting professional conduct and good relations with supervisors, teachers using effective teaching and assessment practices, supervisors possessing effective supervisory leadership skill sets, the provision of periodic training for supervisors, provision of resources and implementing structured and guided supervision for accountability in schools. Recommendations made include the Ghana Education Service (GES) re-orientating teachers on their professional values and attitudes in improving teaching and learning, school heads and supervision experts creating awareness campaigns on the danger of teachers’ resistance to supervisors' roles in schools, school management teams collaborating with instructional experts to organise in-service training to equip teachers with pedagogical strategies, and inclusive practices, fostering creativity and the application of appropriate assessment methods, the Ghana Education Service working with leadership experts to equip all supervisors with supervisory leadership skill sets and also providing schools and supervisors with all the resources and implementing a structured reward system to recognize outstanding performance in supervision.