Abstract: Background: Burnout among Nigerian nurses in tertiary hospitals is a significant issue, leading to adverse effects on both nurse wellbeing and patient outcomes. Purpose: This review aims to explore the key predictors of burnout among nurses in Nigerian tertiary hospitals and examine the coping strategies and interventions that can mitigate its impact. Methods: A literature review was conducted focusing on work-related, socio-demographic, and systemic factors influencing burnout. Findings: Key predictors of burnout among Nigerian nurses include high nurse-patient ratios, long working hours, and inadequate administrative support. Effective coping strategies include implementing peer support programs, scheduling regular breaks, promoting work-life balance through flexible scheduling, and improving staffing levels to mitigate burnout. Implications for Policy and Practice: There is a need for systemic reforms, including improved staffing ratios, better working conditions, and mental health support for nurses. These changes are crucial for reducing burnout and enhancing nurse retention to improve care quality and patient safety.