Abstract: Diabetes mellitus (DM) is among the most common long-term conditions worldwide. He complex persistent disease associated with high blood glucose or hyperglycemia caused by insulin secretion, potency, or both. In this study, the concentration of C-reactive protein was precisely measured and the potential association that might exist between them was explored in T2DM patients. In type 2 diabetics, numerous recent investigations have shown a correlation between CRP and renal impairment. The purpose of this study was to determine whether C-reactive protein and diabetic kidney disease (DKD) are related in Ramadi City residents with type 2 diabetes mellitus. The study was Ninety samples, included 40 healthy samples and 50 patient samples, whose ages ranged from 11 to 50 years, were collected from Ramadi Teaching Hospital in Anbar - Ramadi from October 2024 to February 2025. Four ml of fresh blood was drawn by vein puncture with plastic syringe from each patient and healthy human. The blood specimen was shifted to a plain tube, after which the tube was centrifuged for 10 mins at (3000 xg). Serum was then aliquots into several Eppendorf tubes then kept frozen at -20 °C until used. The serum levels of C-reactive protein were determined by the Cobas Integra 400 plus device, and by the color reactions, the serum glucose levels،creatinine and urea were measured Spectrophotometer (Apple-303). The findings of this thesis, based on age comparison, indicated no significant difference between the patient group and the healthy control group. The mean ages of the patient group and the healthy group were 29.80 years and 32.79 years, respectively. The study's findings demonstrated that the concentrations of C-reactive protein (CRP) and fasting serum glucose (F.S. G) were considerably greater in those with type 2 diabetes mellitus (T2DM) than in the group of healthy people, with recorded values of 16.17 ± 2.823 mg/L for CRP and 252.7 ± 109.3 mg/dl for F.S.G. Pearson correlation analysis revealed no significant correlation between sex or age and the C-reactive protein levels in serum and glucose (P > 0.05). Additionally, no significant correlation was found between serum C-reactive protein and glucose levels (P > 0.05). Increased levels of C-reactive protein (CRP) are seen in people with type 2 diabetes mellitus (T2DM), and they may have a role in the development of diabetic kidney disease (DKD) by promoting inflammation.