Background: Liver cirrhosis is a chronic liver disease characterized by fibrosis and inflammation, leading to altered liver function and systemic changes. Several haematological and biochemical abnormalities have been reported in patients with liver cirrhosis. Objective: This study aimed to evaluate the levels of red cell indices and aspartate aminotransferase (AST) in patients diagnosed with liver cirrhosis at Specialist Hospital Umuguma, Owerri. Methods: A total of 60 subjects (30 patients with liver cirrhosis and 30 healthy controls) were recruited. After obtaining informed consent, five millilitres of venous blood samples were collected. Two milliliters were dispensed into EDTA containers for hematological analysis, and three milliliters into plain containers for biochemical assays. AST levels were determined from serum, while red cell indices were evaluated from whole blood. Data were analyzed using SPSS version 27 with t-tests, correlations, and significance set at p<0.05 Results: The mean values of AST (27.10±15.20) IU/L and RDW (17.00±2.61) % were significantly higher in patients with chronic liver cirrhosis when compared to controls (4.63±1.94) IU/L and (12.27±1.23) % (t= 8.03, p= 0.000, t=8.98, p=0.000). That of PCV (24.03±4.72)%, Hb (8.09±1.50)g/dl, RBC (x106/ul)mg/dl, MCV (75.17±4.65)fl, MCH (26.13±3.32) pg and MCHC (33.40±2.37)% were significantly lower in patients with chronic liver cirrhosis when compared to controls (37.03±4.07)%, (12.99±1.36)g/dl, (4.16±0.39)mg/dl, (89.17±7.34)fl, (31.20±1.75)pg and (34.83±1.82)%. (t=11.43, p=0.000; t=13.21, p=0.000; t=6.59, p=0.000; t=8.82, p=0.000; t=7.39, p=0.000; t=2.63, p=0.011). There was no significant difference in the mean values of AST (26.79±15.93)IU/L, MCV (75.32±4.99)fl, MCH (26.05±3.63)pg, MCHC (33.37±2.26)% in male patients with chronic liver cirrhosis when compared to females (27.64±14.58)IU/L, (74.91±4.23)fl, (26.27±2.87)pg and (33.45±2.66)% (t=0.15, p=0.886; t=0.23, p=0.822; t=0.17, p=0.865; t=0.09, p=0.926).The mean values of PCV (25.95±3.94)%, Hb (8.72±1.22)g/dl and RBC (x106/ul) mg/dl were significantly raised in male patients with chronic liver cirrhosis when compared to females (20.73±4.19)%, (7.02±1.36)g/dl and (2.75±0.54)mg/dl (t=3.42, p=0.002; t=3.53, p=0.003; t=3.29, p=0.003).The mean values of RDW (15.89±2.02) % was significantly lower in male patients with chronic liver cirrhosis when compared to females (18.91±2.47)% (t=3.63, p=0.001). There was no significant difference in the mean values of AST (25.94±11.89)IU/L, PCV (23.06±3.99)%, HB (7.84±1.36)g/dl, RBC (x106/ul)mg/dl, MCV (74.50±4.88)fl, MCH (26.33±3.86)pg, MCHC (33.50±2.26)% and (17.28±2.74)% in patients with chronic liver cirrhosis of ages (40-60)yrs when compared to patients with chronic liver cirrhosis of ages (>60)yrs(31.30±20.70) IU/L, (24.80±5.71)%, (8.25±1.73)g/dl, (3.23±0.80)mg/dl, (75.90±4.70)fl, (25.90±2.64)pg, (33.30±2.87)% and (16.60±2.46)% (t=0.87, p=0.390; t=0.95, p=0.351; t=0.69, p=0.493; t=0.33, p=0.743; t=0.74, p=0.468; t=0.32, p=0.755; t=0.20, p=0.841). There was a non-significant negative correlation of AST with PCV (r=-0.11, p=0.554), Hb (r=-0.78, p=0.687), RBC (r=-0.10, p=0.588), MCV (r=-0.08 p=0.672) and MCHC (r=-0.28, p=0.127) in Patients with Chronic Liver Cirrhosis. Correlation of AST with MCH (r=0.25, p=0.174) and RDW (r=0.07, p=0.729) in Patients with Chronic Liver Cirrhosis showed a non – significant association. Conclusion: Elevated AST and RDW are significantly associated with liver cirrhosis. These parameters, alongside red cell indices, may aid in the clinical assessment and diagnosis of patients with suspected liver cirrhosis.