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South Asian Research Journal of Applied Medical Sciences (SARJAMS)
Volume-7 | Issue-03
Case Report
Leukocytoclastic Vasculitis Associated with Rheumatoid Arthritis and Sjögren’s Syndrome
Grecia Chávez-Chavira
Published : June 23, 2025
DOI : https://doi.org/10.36346/sarjams.2025.v07i03.004
Abstract
Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis that primarily affects superficial postcapillary venules. Histopathological examination reveals predominantly neutrophilic inflammation along with leukocytoclasia. The exact incidence of LCV is not fully understood. Clinically, LCV typically manifests as palpable purpura that can appear anywhere on the body, although it frequently affects the lower limbs. It can develop at any age, but it is more frequent in adults. LCV may be triggered by various factors, including infections, autoimmune disorders, neoplasms, or medications; in some cases, it may be idiopathic, accounting for up to half of all instances. Typically, the condition is mild to moderate, some patients may be asymptomatic, and can improve with supportive care measures. Diagnosis is made through clinical assessment, laboratory tests, and skin biopsy. Treatment should be dictated according to the etiology and most of the cases is symptomatic. We present the case of a 55-year-old woman with autoimmune conditions who presented with abdominal pain and disseminated palpable purpura.

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