The article discusses the effectiveness of inhalation of highly concentrated oxygen in patients with heart failure in large cities: quality of life, frequency of hospitalization and survival. Matherials and methods of investigation: In the study were included 100 people (age is from 50 to 74 years, mean age is 62.3±8.52 years, 50 male and 50 female including) with the heart failure of II-III functional classes (NYHA) on the basis of ischemic heart disease. Examination of the patients included a 6-minute walk test, an assessment of the quality of life using the SF-36 and MLHFQ questionnaires. Endpoint frequency analysis (annual mortality and hospitalization rate analisys) has used. The results of the study: It was found that a year after the start of controlled monitoring, the quality of life of patients who daily, in combination with the main treatment used inhalations of highly concentrated oxygen (group 2), probably improved (p<0.05) due to all its parts of the physical component of health (PF, RP, BP, GH). The improvement in quality of life was also due to the refining of the parts of the emotional component of health (VT, SF, RE and MH, p<0.05). In both observation groups, the quality of life was improved according to the MLHFQ questionnaire - the total number of points (p<0.05), the number of points in the physical (p<0.05) and emotional spheres (p<0.05). It was proved that during the oneyear of observation in both groups there were significant changes and improvement in the test results with a 6-minute walk with increasing distance traveled (in group 1 - from 335.8±34.6 to 378.2±25.4 meters, p<0.05, in the second group - from 324.2±22.8 to 412.7±35.1 meters, p<0.05). A more significant increase was observed in group 2, p<0.05. According to the Kaplan-Meyer survival analysis of the cumulative frequency of endpoints (survival and hospitalization) of patients there was a significant discrepancy between the observation groups. The effectiveness of combination therapy with the inclusion of inhalations of highly concentrated oxygen in patients with heart failure to reduce the frequency of clinically important cardiovascular events was 10%, p<0.05.