The purpose of this study was to ascertain how oral administration of 30% and 40% chitosan nanoparticles on bisphenol-A affected the lipid profile, renal function, and liver enzyme parameters (ALT, AST, and ALP) in white male rats. The liver enzyme markers AST, ALT, ALP, urea, creatinine, triglycerides TG, cholesterol TC, low-density lipoprotein LDL, and very-low-density lipoprotein "vLDL" were all significantly elevated (p < 0.05) by bisphenol-A, while the concentration of high-density lipoprotein HDL decreased. While a significant decrease was observed in the parameters of liver enzymes, urea, creatinine, triglycerides (TG), cholesterol (TC), low-density lipoprotein (LDL), and very-low-density lipoprotein (vLDL) and an increase in the value of high-density lipoprotein (HDL) when treated with chitosan nanoparticles.