The purpose is to compare the efficacy of various hand rub brands against specific skin-colonizing bacteria due to the widespread use of hand disinfectants, due to COVID-19's contagious nature, highlighting the importance of hand hygiene in reducing nosocomial infections and cross-transmission. Thirty workers from the Iraqi Scientific Research Commission’s laboratories, split into two groups for administrative and scientific work to provide bacterial samples. A total of thirty samples of bacteria were acquired. Based on their popularity and frequent use in Baghdad, fifteen different hand sanitizers from various brands were purchased for this study. The well diffusion agar test was used in the experiment to assess the bacterial activity of the hand sanitizers used in the study. The majority of sanitizers were unable to eradicate every type of bacterial species identified during the study. The gel sanitizer with 93% ethyl alcohol was successful in eliminating every bacterial strain identified, except for one species. Meanwhile, a liquid sanitizer with 70% alcohol was unable to eradicate even a single strain of bacteria. Our study's findings demonstrated that the alcohol-free disinfectant outperformed the sanitizer with an alcohol content ranging from 60 to 93% in terms of bacterial control.