This study aims to determine the influence of Capital Structure which is limited by Debt to Equity Ratio, Profitability which is limited by Return on Equity (ROE), and Company Size to Company Value (Price to Book Value). The object of this research is pharmaceutical subsector company period 2012 - 2015. The data used is secondary data obtained through Indonesia Stock Exchange. The research design used is causal research. The sampling technique used purposive sampling method. From the method obtained 7 companies that meet the criteria of a total of 11 companies during the four-year observation period. The analysis technique used is panel data regression analysis wirh t-statistic test. The results of this study are Retrun on Equity (ROE) has a positive and significant influence on Price to Book Value, but Debt to Equty Ratio (DER) has a negative and not significant influence on Price to Book Value, and Company Size (Size) has a negative and not significant influence on Price to Book Value of pharmaceutical industry companies listed on the Indonesia Stock Exchange (BEI) in period 2012-2015.